Big Cypress Seminole Indian Reservation

 region, Native American reservation/reserve

The Big Cypress Indian Reservation is located in southeastern Hendry County and northwestern Broward County in southern Florida in the United States. The reservation lies south of Lake Okeechobee and just north of Alligator Alley. It is located in an area formerly known as "Sam Jones Old Town". Became a protected Federal Indian Reservation in 1936.

The reservation is governed by the Seminole Tribe of Florida's Tribal Council, and is the largest of the five Seminole reservations in the state. The land area is 212.306 km² (81.972 sq mi), and a resident population of 142 persons was reported in the 2000 census. The reservation lies adjacent to the north side of the largest section of the Miccosukee Indian Reservation in western Broward County.

The tribe owns two tourist attractions: Swamp Safari, and The Big Cypress Entertainment Complex. The 2007 Langerado Festival is held there, which was also the former site of Phish's Big Cypress concert (a large cow pasture).