U.S. Highways 18 & 385

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US Route 18 isn't designated by itself until almost 90 miles from its western endpoint. It begins concurrent with US 20 at Interstate 25 exit 126 near Orin, WY. The road heads east to Lusk, then runs concurrent with US 85 until it splits off. US 18 passes through southern South Dakota and into Iowa. It crosses I-35 at Clear Lake, IA and enters Wisconsin at Prairie du Chien, WI. It ends in Milwaukee, WI at the intersection of East Michigan Street (which it is on) and Lincoln Memorial Drive.

US 385 is signed from Big Bend National Park in Texas on a direct northerly route to Deadwood, SD (US 85). It runs through west Texas, eastern Colorado, western Nebraska and western South Dakota.