Ancient Antioch (Antakya district)

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Remains of old city wall of Antioch.
After Alexander's death in 323 BC, his generals divided up the territory he had conquered. Seleucus I Nicator won the territory of Syria, and he proceeded to found four "sister cities" in northwestern Syria, one of which was Antioch, a city named, according to Suda, after his son Antiochus. He is reputed to have built sixteen Antiochs.
Seleucus founded Antioch on a site chosen through ritual means. An eagle, the bird of Zeus, had been given a piece of sacrificial meat and the city was founded on the site to which the eagle carried the offering. Seleucus did this on the 22nd day of the month of Artemisios in the twelfth year of his reign (equivalent to May 300 BC). Antioch soon rose above Seleucia Pieria to become the Syrian capital.
en.wikipedia.org/wiki/Antioch#Foundation_by_Seleucus_I